DRP1 Promotes BRAF^V600E-Driven Tumor Progression and Metabolic Reprogramming in Colorectal Cancer.

ABSTRACT:

Background

Mitochondria are highly dynamic organelles which remain in a continuous state of fission/ fusion dynamics to meet the metabolic needs of a cell. However, this fission/fusion dynamism has been reported to be dysregulated in most cancers. Such enhanced mitochondrial fission is demonstrated to be positively regulated by some activating oncogenic mutations; such as those of KRAS (Kristen rat sarcoma viral oncogene homologue) or BRAF (B- rapidly accelerated fibrosarcoma), thereby increasing tumor progression/ chemotherapeutic resistance and metabolic deregulation. However, the underlying mechanism(s) are still not clear, thus highlighting the need to further explore possible mechanism(s) of intervention. We sought to investigate how BRAF^V600E driven CRC (colorectal

SUBMITTER: Padder RA 

PROVIDER: S-EPMC7961078 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature