The Identification and Validation of Two Heterogenous Subtypes and a Risk Signature Based on Ferroptosis in Hepatocellular Carcinoma.

ABSTRACT:

Background

Ferroptosis is essential for tumorigenesis and progression of hepatocellular carcinoma (HCC). The heterogeneity of ferroptosis and its relationship with tumor microenvironment (TME) have still remain elusive.

Methods

Based on 74 ferroptosis related genes (FRGs) and 3,933 HCC samples from 32 datasets, we comprehensively explored the heterogenous ferroptosis subtypes. The clinical significance, functional status, immune infiltration, immune escape mechanisms, and genomic alterations of different subtypes were further investigated.

Results

We identified and validated two heterogeneous ferroptosis subtypes: C1 was metabolism^lowimmunity^high subtype and C2 was metabolism^highimmunity^low subtype. Compared to C2, C1 owned

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7961086 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature