Associations of ARMS2 and CFH Gene Polymorphisms with Neovascular Age-Related Macular Degeneration.

ABSTRACT:

Purpose

This study aimed to determine the association of ARMS2 A69S, ARMS2 del443ins54, and CFH Y402H polymorphisms with neovascular age-related macular degeneration (nAMD) for the first time in an Indonesian population.

Patients and methods

Our case-control study involved 104 nAMD and 100 control subjects. AMD diagnosis was evaluated by retinal specialists based on color fundus photography and optical coherence tomography. The polymorphisms on CFH Y402H and ARMS2 A69S were analyzed by PCR-restriction fragment length polymorphism (PCR-RFLP), whereas ARMS2 del443ins54 was evaluated by PCR-based assay.

Results

Significant allelic associations with nAMD were detected on all polymorphisms (P<0.05), with stronger association with t

SUBMITTER: Supanji S 

PROVIDER: S-EPMC7961131 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature