Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal peptide (Part 2): biology and clinical importance in central nervous system and inflammatory disorders.

ABSTRACT:

Purpose of review

To discuss recent advances of vasoactive intestinal peptide/pituitary adenylate cyclase-activating polypeptide (VIP/PACAP) receptors in the selected central nervous system (CNS) and inflammatory disorders.

Recent findings

Recent studies provide evidence that PACAP plays an important role in a number of CNS disorders, particularly the pathogenesis of headaches (migraine, etc.) as well as posttraumatic stress disorder and drug/alcohol/smoking addiction. VIP has important therapeutic effects in a number of autoimmune/inflammatory disorder such as rheumatoid arthritis. In some cases, these insights have advanced to therapeutic trials.

Summary

Recent insights from studies of VIP/PACAP and their receptors in both CNS disorders (migraine, posttraumatic stre

SUBMITTER: Moody TW 

PROVIDER: S-EPMC7961158 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature