SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome.

ABSTRACT: In late 2019, a global pandemic occurred. The causative agent was identified as a member of the Coronaviridae family, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, we present an analysis on the substances identified in the human metabolome capable of binding the active site of the SARS-CoV-2 main protease (M^pro). The substances present in the human metabolome have both endogenous and exogenous origins. The aim of this research was to find molecules whose biochemical and toxicological profile was known that could be the starting point for the development of antiviral therapies. Our analysis revealed numerous metabolites-including xenobiotics-that bind this protease, which are essential to the lifecycle of the virus. Among these substan

SUBMITTER: Sardanelli AM 

PROVIDER: S-EPMC7961382 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature