Additive Role of Immune System Infiltration and Angiogenesis in Uveal Melanoma Progression.

ABSTRACT: Uveal melanoma (UM) is a malignant tumor that arises in the melanocytes of the uveal tract. It is the most frequent eye cancer, and despite new therapeutic approaches, prognosis is still poor, with up to 50% of patients developing metastasis with no efficient treatment options available. In contrast to cutaneous melanoma, UM is considered an "immune-cold" tumor due to the low mutational burden and the unique immunosuppressive microenvironment. To gain insight into the role of the UM microenvironment in regard to prognosis and metastatic progression, we have performed a pool analysis characterizing the UM microenvironment by using a bioinformatic approach. A variety of scores based on gene expression measuring stromal infiltration were calculated and used to assess association with prognosi

SUBMITTER: Garcia-Mulero S 

PROVIDER: S-EPMC7961481 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature