Genetic Regulation of Physiological Reproductive Lifespan and Female Fertility.

ABSTRACT: There is substantial genetic variation for common traits associated with reproductive lifespan and for common diseases influencing female fertility. Progress in high-throughput sequencing and genome-wide association studies (GWAS) have transformed our understanding of common genetic risk factors for complex traits and diseases influencing reproductive lifespan and fertility. The data emerging from GWAS demonstrate the utility of genetics to explain epidemiological observations, revealing shared biological pathways linking puberty timing, fertility, reproductive ageing and health outcomes. The observations also identify unique genetic risk factors specific to different reproductive diseases impacting on female fertility. Sequencing in patients with primary ovarian insufficiency (POI) have i

SUBMITTER: McGrath IM 

PROVIDER: S-EPMC7961500 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature