Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins.

ABSTRACT: Members of the human Zyxin family are LIM domain-containing proteins that perform critical cellular functions and are indispensable for cellular integrity. Despite their importance, not much is known about their structure, functions, interactions and dynamics. To provide insights into these, we used a set of in-silico tools and databases and analyzed their amino acid sequence, phylogeny, post-translational modifications, structure-dynamics, molecular interactions, and functions. Our analysis revealed that zyxin members are ohnologs. Presence of a conserved nuclear export signal composed of LxxLxL/LxxxLxL consensus sequence, as well as a possible nuclear localization signal, suggesting that Zyxin family members may have nuclear and cytoplasmic roles. The molecular modeling and structural an

SUBMITTER: Siddiqui MQ 

PROVIDER: S-EPMC7961639 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature