Randomized, controlled trial of lasmiditan over four migraine attacks: Findings from the CENTURION study.

ABSTRACT:

Background

We present findings from the multicenter, double-blind Phase 3 study, CENTURION. This study was designed to assess the efficacy of and consistency of response to lasmiditan in the acute treatment of migraine across four attacks.

Methods

Patients were randomized 1:1:1 to one of three treatment groups - lasmiditan 200 mg; lasmiditan 100 mg; or a control group that received placebo for three attacks and lasmiditan 50 mg for either the third or fourth attack. The primary endpoints were pain freedom at 2 h (first attack) and pain freedom at 2 h in ≥2/3 attacks. Secondary endpoints included pain relief, sustained pain freedom and disability freedom. Statistical testing used a logistic regression model and graphical methodology to control for multiplicity.

Results

SUBMITTER: Ashina M 

PROVIDER: S-EPMC7961651 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature