Spectroscopic Signature of Red Blood Cells in a D-Galactose-Induced Accelerated Aging Model.

ABSTRACT: This work presents a semi-quantitative spectroscopic approach, including FTIR-ATR and Raman spectroscopies, for the biochemical analysis of red blood cells (RBCs) supported by the biochemical, morphological and rheological reference techniques. This multi-modal approach provided the description of the RBC alterations at the molecular level in a model of accelerated aging induced by administration of D-galactose (D-gal), in comparison to natural aging. Such an approach allowed to conclude that most age-related biochemical RBC membrane changes (a decrease in lipid unsaturation and the level of phospholipids, or an increase in acyl chain shortening) as well as alterations in the morphological parameters and RBC deformability are well reflected in the D-gal model of accelerated aging. Similarl

SUBMITTER: Blat A 

PROVIDER: S-EPMC7961785 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature