The asthma evidence base: a call for core outcomes in interventional trials.

ABSTRACT:

Objectives

Biologic therapies are emerging as an option to treat a subset of patients with severe asthma, however no direct comparison between these agents has been conducted. Furthermore, heterogeneity of outcomes in clinical trials makes it difficult to compare these agents and traditional therapies. The extent to which this heterogeneity exists has major implications for evidence-based decisions and is yet to be fully reported. We conducted a literature search to examine outcomes currently being used in clinical trials for asthma.

Data sources

The Cochrane Library and Clinicaltrials.gov were searched for clinical trials of asthma interventions.

Study selections

We limited our search to phase 2 through 4 clinical trials in adults, as early-phase trials tend to have

SUBMITTER: Tejwani V 

PROVIDER: S-EPMC7961946 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature