Acid sphingomyelinase deficiency exacerbates LPS-induced experimental periodontitis.

ABSTRACT:

Background

Mutation of the gene for acid sphingomyelinase (ASMase) causes Niemann-Pick disease. However, the effect of ASMase deficiency on periodontal health is unknown. Periodontal disease is a disease resulting from infection and inflammation of periodontal tissue and alveolar bone that support the teeth. The goal of this study was to determine the role of ASMase deficiency in periodontal inflammation and alveolar bone loss.

Methods

We induced periodontitis in wild-type and ASMase-deficient (ASMase^-/- ) mice with periodontal lipopolysaccharide (LPS) injection and compared the alveolar bone loss and periodontal inflammation between these mice.

Results

Results showed that ASMase deficiency did not significantly change metabolic parameters, but exacerbated

SUBMITTER: Li Y 

PROVIDER: S-EPMC7962143 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature