Zn²⁺-dependent suppression of vascular smooth muscle intimal hyperplasia from biodegradable zinc implants.

ABSTRACT: Biodegradable arterial implants based on zinc have been found to suppress neointimal hyperplasia, suggesting that biodegradable materials containing zinc may be used to construct vascular implants with a reduced rate of restenosis. However, the molecular mechanism has remained unclear. In this report, we show that zinc-containing materials can be used to prevent neointimal formation when implanted into the rat aorta. Indeed, neointimal cells were significantly more TUNEL positive and alpha-actin negative at the interface of biodegradable zinc vs. biostable platinum implants, in association with greater caspase-3 activity. Although zinc stimulated extensive neointimal smooth muscle cell (SMC) death, macrophage and proinflammatory markers CD68 and iNOS were not increased in neointimal tissue

SUBMITTER: Guillory RJ 

PROVIDER: S-EPMC7962177 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature