GAKTpore: Stereological Characterisation Methods for Porous Foams in Biomedical Applications.

ABSTRACT: In tissue engineering, scaffolds are a key component that possess a highly elaborate pore structure. Careful characterisation of such porous structures enables the prediction of a variety of large-scale biological responses. In this work, a rapid, efficient, and accurate methodology for 2D bulk porous structure analysis is proposed. The algorithm, "GAKTpore", creates a morphology map allowing quantification and visualisation of spatial feature variation. The software achieves 99.6% and 99.1% mean accuracy for pore diameter and shape factor identification, respectively. There are two main algorithm novelties within this work: (1) feature-dependant homogeneity map; (2) a new waviness function providing insights into the convexity/concavity of pores, important for understanding the influence

SUBMITTER: Sheppard G 

PROVIDER: S-EPMC7962185 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature