The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma.

ABSTRACT:

Background

Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased expression of DLG2, a gene residing in the deleted region. DLG2 has a number of different isoforms with the main difference is the presence or absence of a L27 domain. The L27 domain containing DLG proteins can form complexes with CASK/MPP and LIN7 protein family members, which will control cell polarity and signaling.

Methods

We evaluated the DLG gene family and the LIN7 gene family for their expression in differently INSS staged neuroblastoma from publically available data and primary tumors, we included two distinct DLG1 and DLG2 N-terminal transcript isofo

SUBMITTER: Keane S 

PROVIDER: S-EPMC7962242 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature