Single-cell morphological characterization of CRH neurons throughout the whole mouse brain.

ABSTRACT:

Background

Corticotropin-releasing hormone (CRH) is an important neuromodulator that is widely distributed in the brain and plays a key role in mediating stress responses and autonomic functions. While the distribution pattern of fluorescently labeled CRH-expressing neurons has been studied in different transgenic mouse lines, a full appreciation of the broad diversity of this population and local neural connectivity can only come from integration of single-cell morphological information as a defining feature. However, the morphologies of single CRH neurons and the local circuits formed by these neurons have not been acquired at brain-wide and dendritic-scale levels.

Results

We screened the EYFP-expressing CRH-IRES-Cre;Ai32 mouse line to reveal the morphologies of individual

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7962243 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature