Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZ^WT/Q1038R mouse model of autism spectrum disorder.

ABSTRACT: Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by core symptoms of impaired social behavior and communication. Recent studies have suggested that the oxytocin system, which regulates social behavior in mammals, is potentially involved in ASD. Mouse models of ASD provide a useful system for understanding the associations between an impaired oxytocin system and social behavior deficits. However, limited studies have shown the involvement of the oxytocin system in the behavioral phenotypes in mouse models of ASD. We have previously demonstrated that a mouse model that carries the ASD patient-derived de novo mutation in the pogo transposable element derived with zinc finger domain (POGZ^WT/Q1038R mice), showed ASD-like social behavioral

SUBMITTER: Kitagawa K 

PROVIDER: S-EPMC7962304 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature