MiR-4448 is involved in deltamethrin resistance by targeting CYP4H31 in Culex pipiens pallens.

ABSTRACT:

Background

Culex pipiens (Cx. pipiens) complex, which acts as a vector of viruses and is widespread and abundant worldwide, including West Nile virus, Japanese encephalitis virus, and Sindbis virus, can cause serious vector-borne diseases affecting human health. Unfortunately, mosquitoes have developed deltamethrin resistance because of its long-term overuse, representing a major challenge to mosquito control. Understanding the molecular regulatory mechanisms of resistance is vital to control mosquitoes. MicroRNAs (miRNAs) are short non-coding RNAs that have been demonstrated to be important regulators of gene expression across a wide variety of organisms, which might function in mosquito deltamethrin resistance. In the present study, we aimed to investigate the regulatory function

SUBMITTER: Li X 

PROVIDER: S-EPMC7962327 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature