Genome-scale model reconstruction of the methylotrophic yeast Ogataea polymorpha.

ABSTRACT:

Background

Ogataea polymorpha is a thermotolerant, methylotrophic yeast with significant industrial applications. While previously mainly used for protein synthesis, it also holds promise for producing platform chemicals. O. polymorpha has the distinct advantage of using methanol as a substrate, which could be potentially derived from carbon capture and utilization streams. Full development of the organism into a production strain and estimation of the metabolic capabilities require additional strain design, guided by metabolic modeling with a genome-scale metabolic model. However, to date, no genome-scale metabolic model is available for O. polymorpha.

Results

To overcome this limitation, we used a published reconstruction of the closely related yeast Komagataella phaffii a

SUBMITTER: Liebal UW 

PROVIDER: S-EPMC7962355 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature