Novel Combinatorial Approaches to Tackle the Immunosuppressive Microenvironment of Prostate Cancer.

ABSTRACT: Prostate cancer (PCa) is the second-most common cancer in men worldwide and treatment options for patients with advanced or aggressive prostate cancer or recurrent disease continue to be of limited success and are rarely curative. Despite immune checkpoint blockade (ICB) efficacy in some melanoma, lung, kidney and breast cancers, immunotherapy efforts have been remarkably unsuccessful in PCa. One hypothesis behind this lack of efficacy is the generation of a distinctly immunosuppressive prostate tumor microenvironment (TME) by regulatory T cells, MDSCs, and type 2 macrophages which have been implicated in a variety of pathological conditions including solid cancers. In PCa, Tregs and MDSCs are attracted to TME by low-grade chronic inflammatory signals, while tissue-resident type 2 macropha

SUBMITTER: Shackleton EG 

PROVIDER: S-EPMC7962457 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature