Comparative Proteome Research in a Zebrafish Model for Vanishing White Matter Disease.

ABSTRACT: Vanishing white matter (VWM) disease is a genetic leukodystrophy leading to severe neurological disease and early death. VWM is caused by bi-allelic mutations in any of the five genes encoding the subunits of the eukaryotic translation factor 2B (EIF2B). Previous studies have attempted to investigate the molecular mechanism of VWN by constructing models for each subunit of EIF2B that causes VWM disease. The underlying molecular mechanisms of the way in which mutations in EIF2B3 result in VWM are largely unknown. Based on our recent results, we generated an eif2b3 knockout (eif2b3^-/-) zebrafish model and performed quantitative proteomic analysis between the wild-type (WT) and eif2b3^-/- zebrafish, and identified 25 differentially expressed proteins.

SUBMITTER: Kim D 

PROVIDER: S-EPMC7962458 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature