Mimicking the Endothelium: Dual Action Heparinized Nitric Oxide Releasing Surface.

ABSTRACT: The management of thrombosis and bacterial infection is critical to ensure the functionality of medical devices. While administration of anticoagulants is the current antithrombotic clinical practice, a variety of complications, such as uncontrolled hemorrhages or heparin-induced thrombocytopenia, can occur. Additionally, infection rates remain a costly and deadly complication associated with use of these medical devices. It has been hypothesized that if a synthetic surface could mimic the biochemical mechanisms of the endothelium of blood vessels, thrombosis could be reduced, anticoagulant use could be avoided, and infection could be prevented. Herein, the interfacial biochemical effects of the endothelium were mimicked by altering the surface of medical grade silicone rubber (SR). Surfac

SUBMITTER: Devine R 

PROVIDER: S-EPMC7962625 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature