Active Release of an Antimicrobial and Antiplatelet Agent from a Nonfouling Surface Modification.

ABSTRACT: Two major challenges faced by medical devices are thrombus formation and infection. In this work, surface-tethered nitric oxide (NO)-releasing molecules are presented as a solution to combat infection and thrombosis. These materials possess a robust NO release capacity lasting ca. 1 month while simultaneously improving the nonfouling nature of the material by preventing platelet, protein, and bacteria adhesion. NO's potent bactericidal function has been implemented by a facile surface covalent attachment method to fabricate a triple-action coating-surface-immobilized S-nitroso- N-acetylpenicillamine (SIM-S). Comparison of NO loading amongst the various branching configurations is shown through the NO release kinetics over time and the cumulative NO release. Biological characterization is p

SUBMITTER: Goudie MJ 

PROVIDER: S-EPMC7962626 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature