A Web Server for Designing Molecular Switches Composed of Two Interacting RNAs.

ABSTRACT: The programmability of RNA-RNA interactions through intermolecular base-pairing has been successfully exploited to design a variety of RNA devices that artificially regulate gene expression. An in silico design for interacting structured RNA sequences that satisfies multiple design criteria becomes a complex multi-objective problem. Although multi-objective optimization is a powerful technique that explores a vast solution space without empirical weights between design objectives, to date, no web service for multi-objective design of RNA switches that utilizes RNA-RNA interaction has been proposed. We developed a web server, which is based on a multi-objective design algorithm called MODENA, to design two interacting RNAs that form a complex in silico. By predicting the secondary structure

SUBMITTER: Taneda A 

PROVIDER: S-EPMC7962656 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature