Statin Use and Benefits of Thyroid Function: A Retrospective Cohort Study.

ABSTRACT:

Purpose

Previous studies have suggested that cholesterol may influence thyroid function. Since statins are widely used for their cholesterol-lowering effect, we aimed to assess the association between statin use and thyroid function, and also to explore the role of the cholesterol-lowering effect in it.

Methods

We performed a retrospective cohort study derived from REACTION study. Eligible subjects receiving statin therapy were included in the statin group, and sex-, age-, total cholesterol (TC)-, and thyroid function-matched participants without lipid-lowering therapy were included in the control group. The median follow-up time was three years. Outcomes of thyroid function were evaluated at the end of follow-up. We used multivariable regression models to assess the associa

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7962670 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature