Prediction of cognitive response to surgery in elderly patients with primary hyperparathyroidism.

ABSTRACT:

Background

Primary hyperparathyroidism (pHPT) can be associated with potentially reversible cognitive impairment, which is occasionally mistaken for natural ageing and dementia. The aim was to evaluate short-term medical normalization of hypercalcaemia in surgical decision-making for elderly patients with mild cognitive deficiency.

Methods

Patients with pHPT were included in a prospective observational study. A test panel including the Montreal Cognitive Assessment (MoCA) and validated tools for estimation of psychological status (Hospital Anxiety and Depression Scale, HADS), and muscle strength (timed-stands test, TST) was applied at baseline, after 4 weeks of calcimimetic treatment, and after parathyroidectomy. Mild cognitive impairment was defined by a MoCA score below 26

SUBMITTER: Koman A 

PROVIDER: S-EPMC7962724 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature