Structural Correlates of the Sensorimotor Cerebellum in Parkinson's Disease and Essential Tremor.

ABSTRACT:

Background

Parkinson's disease (PD) and essential tremor (ET) are commonly encountered movement disorders. Pathophysiologic processes that localize to the cerebellum are described in both. There are limited studies investigating cerebellar structural changes in these conditions, largely because of inherent challenges in the efficiency of segmentation.

Methods

We applied a novel multiatlas cerebellar segmentation method to T1-weighted images in 282 PD and 111 essential tremor patients to define 26 cerebellar lobule volumes. The severity of postural and resting tremor in both populations and gait and postural instability in PD patients were defined using subscores of the UPDRS and Washington Heights-Inwood Genetic Study motor scales. These clinical measurements were related to

SUBMITTER: Lopez AM 

PROVIDER: S-EPMC7962800 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature