Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development.

ABSTRACT: Nuclear factor of activated T cells (NFAT), which is the pharmacological target of immunosuppressants cyclosporine and tacrolimus, has been shown to play an important role not only in T cells (immune system), from which their name is derived, but also in many biological events. Therefore, functional and/or structural abnormalities of NFAT are linked to the pathogenesis of diseases in various organs. The NFAT protein family consists of five isoforms, and each isoform performs diverse functions and has unique expression patterns in the target tissues. This diversity has made it difficult to obtain ideal pharmacological output for immunosuppressants that inhibit the activity of almost all NFAT family members, causing serious and wide-ranging side effects. Moreover, it remains unclear whether

SUBMITTER: Kitamura N 

PROVIDER: S-EPMC7962815 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature