Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung.

ABSTRACT: Human stem cell-derived extracellular vesicles (EV) provide many advantages over cell-based therapies for the treatment of functionally compromised tissue beds and organ sites. Here we sought to determine whether human embryonic stem cell (hESC)-derived EV could resolve in part, the adverse late normal tissue complications associated with exposure of the lung to ionizing radiation. The hESC-derived EV were systemically administered to the mice via the retro-orbital sinus to explore the potential therapeutic benefits following exposure to high thoracic doses of radiation (14 Gy). Data demonstrated that hESC-derived EV treatment significantly improved overall survival of the irradiated cohorts (P < 0.001). Increased survival was also associated with significant reductions in lu

SUBMITTER: Montay-Gruel P 

PROVIDER: S-EPMC7962869 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature