A general approach to sensitivity analysis for Mendelian randomization.

ABSTRACT: Mendelian Randomization (MR) represents a class of instrumental variable methods using genetic variants. It has become popular in epidemiological studies to account for the unmeasured confounders when estimating the effect of exposure on outcome. The success of Mendelian Randomization depends on three critical assumptions, which are difficult to verify. Therefore, sensitivity analysis methods are needed for evaluating results and making plausible conclusions. We propose a general and easy to apply approach to conduct sensitivity analysis for Mendelian Randomization studies. Bound et al. (1995) derived a formula for the asymptotic bias of the instrumental variable estimator. Based on their work, we derive a new sensitivity analysis formula. The parameters in the formula include sensitivity

SUBMITTER: Zhang W 

PROVIDER: S-EPMC7962901 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature