Adaptive Changes in the Central Control of Energy Homeostasis Occur in Response to Variations in Energy Status.

ABSTRACT: Energy homeostasis is regulated in coordinate fashion by the brain-gut axis, the homeostatic energy balance circuitry in the hypothalamus and the hedonic energy balance circuitry comprising the mesolimbcortical A10 dopamine pathway. Collectively, these systems convey and integrate information regarding nutrient status and the rewarding properties of ingested food, and formulate it into a behavioral response that attempts to balance fluctuations in consumption and food-seeking behavior. In this review we start with a functional overview of the homeostatic and hedonic energy balance circuitries; identifying the salient neural, hormonal and humoral components involved. We then delve into how the function of these circuits differs in males and females. Finally, we turn our attention to the eve

SUBMITTER: Gastelum C 

PROVIDER: S-EPMC7962960 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature