PKCε Is Required for KRAS-Driven Lung Tumorigenesis.

ABSTRACT: Non-small cell lung cancer (NSCLC) is the most frequent subtype of lung cancer and remains a highly lethal malignancy and one of the leading causes of cancer-related deaths worldwide. Mutant KRAS is the prevailing oncogenic driver of lung adenocarcinoma, the most common histologic form of NSCLC. In this study, we examined the role of PKCϵ, an oncogenic kinase highly expressed in NSCLC and other cancers, in KRAS-driven tumorigenesis. Database analysis revealed an association between PKCϵ expression and poor outcome in patients with lung adenocarcinoma specifically harboring KRAS mutations. A PKCϵ-deficient, conditionally activatable allele of oncogenic Kras (LSL-Kras^G12D ;PKCϵ^-/- mice) demonstrated the requirement of PKCϵ for Kras-driven lung tumor

SUBMITTER: Garg R 

PROVIDER: S-EPMC7962984 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature