Deleterious mutation accumulation and the long-term fate of chromosomal inversions.

ABSTRACT: Chromosomal inversions contribute widely to adaptation and speciation, yet they present a unique evolutionary puzzle as both their allelic content and frequency evolve in a feedback loop. In this simulation study, we quantified the role of the allelic content in determining the long-term fate of the inversion. Recessive deleterious mutations accumulated on both arrangements with most of them being private to a given arrangement. This led to increasing overdominance, allowing for the maintenance of the inversion polymorphism and generating strong non-adaptive divergence between arrangements. The accumulation of mutations was mitigated by gene conversion but nevertheless led to the fitness decline of at least one homokaryotype under all considered conditions. Surprisingly, this fitness degra

SUBMITTER: Berdan EL 

PROVIDER: S-EPMC7963061 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature