Direct Evidence for Prediction Signals in Frontal Cortex Independent of Prediction Error.

ABSTRACT: Predictive coding (PC) has been suggested as one of the main mechanisms used by brains to interact with complex environments. PC theories posit top-down prediction signals, which are compared with actual outcomes, yielding in turn prediction error (PE) signals, which are used, bottom-up, to modify the ensuing predictions. However, disentangling prediction from PE signals has been challenging. Critically, while many studies found indirect evidence for PC in the form of PE signals, direct evidence for the prediction signal is mostly lacking. Here, we provide clear evidence, obtained from intracranial cortical recordings in human surgical patients, that the human lateral prefrontal cortex evinces prediction signals while anticipating an event. Patients listened to task-irrelevant sequences of

SUBMITTER: Durschmid S 

PROVIDER: S-EPMC7963121 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature