Deterioration in right ventricular structure and function over time in patients with heart failure and preserved ejection fraction.

ABSTRACT:

Aims

Prevalent right ventricular (RV) dysfunction (RVD) is associated with increased mortality in patients with heart failure with preserved ejection fraction (HFpEF), but no study has characterized long-term changes in RV structure and function within the same patient.

Methods and results

Patients with unequivocal HFpEF defined by either invasive haemodynamics or hospitalization for pulmonary oedema (n = 271) underwent serial echocardiographic evaluations >6 months apart. Clinical, structural, functional, and haemodynamic characteristics were examined. Over a median of 4.0 years (interquartile range 2.1-6.1), there was a 10% decline in RV fractional area change and 21% increase in RV diastolic area (both P < 0.0001). These changes greatly exceeded corresponding changes in t

SUBMITTER: Obokata M 

PROVIDER: S-EPMC7963126 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature