The haemodynamic basis of lung congestion during exercise in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Increases in extravascular lung water (EVLW) during exercise contribute to symptoms, morbidity, and mortality in patients with heart failure and preserved ejection fraction (HFpEF), but the mechanisms leading to pulmonary congestion during exercise are not well-understood.

Methods and results

Compensated, ambulatory patients with HFpEF (n = 61) underwent invasive haemodynamic exercise testing using high-fidelity micromanometers with simultaneous lung ultrasound, echocardiography, and expired gas analysis at rest and during submaximal exercise. The presence or absence of EVLW was determined by lung ultrasound to evaluate for sonographic B-line artefacts. An increase in EVLW during exercise was observed in 33 patients (HFpEFLW+, 54%), while 28 (46%) did not develop EVLW (

SUBMITTER: Reddy YNV 

PROVIDER: S-EPMC7963140 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature