Epigenetic Changes Governing Scn5a Expression in Denervated Skeletal Muscle.

ABSTRACT: The SCN5A gene encodes the α-subunit of the voltage-gated cardiac sodium channel (Na_V1.5), a key player in cardiac action potential depolarization. Genetic variants in protein-coding regions of the human SCN5A have been largely associated with inherited cardiac arrhythmias. Increasing evidence also suggests that aberrant expression of the SCN5A gene could increase susceptibility to arrhythmogenic diseases, but the mechanisms governing SCN5A expression are not yet well understood. To gain insights into the molecular basis of SCN5A gene regulation, we used rat gastrocnemius muscle four days following denervation, a process well known to stimulate Scn5a expression. Our results show that denervation of rat skeletal muscle induces the express

SUBMITTER: Carreras D 

PROVIDER: S-EPMC7963191 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature