Tensor-valued diffusion MRI differentiates cortex and white matter in malformations of cortical development associated with epilepsy.

ABSTRACT:

Objective

Delineation of malformations of cortical development (MCD) is central in presurgical evaluation of drug-resistant epilepsy. Delineation using magnetic resonance imaging (MRI) can be ambiguous, however, because the conventional T₁ - and T₂ -weighted contrasts depend strongly on myelin for differentiation of cortical tissue and white matter. Variations in myelin content within both cortex and white matter may cause MCD findings on MRI to change size, become undetectable, or disagree with histopathology. The novel tensor-valued diffusion MRI (dMRI) technique maps microscopic diffusion anisotropy, which is sensitive to axons rather than myelin. This work investigated whether tensor-valued dMRI may improve differentiation of cortex and white matter in the

SUBMITTER: Lampinen B 

PROVIDER: S-EPMC7963222 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature