Taurine represses age-associated gut hyperplasia in Drosophila via counteracting endoplasmic reticulum stress.

ABSTRACT: As they age, adult stem cells become more prone to functional decline, which is responsible for aging-associated tissue degeneration and diseases. One goal of aging research is to identify drugs that can repair age-associated tissue degeneration. Multiple organ development-related signaling pathways have recently been demonstrated to have functions in tissue homeostasis and aging process. Therefore, in this study, we tested several chemicals that are essential for organ development to assess their ability to delay intestinal stem cell (ISC) aging and promote gut function in adult Drosophila. We found that taurine, a free amino acid that supports neurological development and tissue metabolism in humans, represses ISC hyperproliferation and restrains the intestinal functional decline seen in

SUBMITTER: Du G 

PROVIDER: S-EPMC7963329 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature