Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals.

ABSTRACT: There is growing interest in studying the genetic contributions to longevity, but limited relevant genes have been identified. In this study, we performed a genetic association study of longevity in a total of 15,651 Chinese individuals. Novel longevity loci, BMPER (rs17169634; p = 7.91 × 10^-15 ) and TMEM43/XPC (rs1043943; p = 3.59 × 10^-8 ), were identified in a case-control analysis of 11,045 individuals. BRAF (rs1267601; p = 8.33 × 10^-15 ) and BMPER (rs17169634; p = 1.45 × 10^-10 ) were significantly associated with life expectancy in 12,664 individuals who had survival status records. Additional sex-stratified analyses identified sex-specific longevity genes. Notably, sex-differential associations were identified in two linkage disequilibrium b

SUBMITTER: Liu X 

PROVIDER: S-EPMC7963337 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature