BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy.

ABSTRACT: Aging clocks dissociate biological from chronological age. The estimation of biological age is important for identifying gerontogenes and assessing environmental, nutritional, or therapeutic impacts on the aging process. Recently, methylation markers were shown to allow estimation of biological age based on age-dependent somatic epigenetic alterations. However, DNA methylation is absent in some species such as Caenorhabditis elegans and it remains unclear whether and how the epigenetic clocks affect gene expression. Aging clocks based on transcriptomes have suffered from considerable variation in the data and relatively low accuracy. Here, we devised an approach that uses temporal scaling and binarization of C. elegans transcriptomes to define a gene set that predicts biological age with a

SUBMITTER: Meyer DH 

PROVIDER: S-EPMC7963339 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature