Understanding the Neurocomputational Mechanisms of Antidepressant Placebo Effects.

ABSTRACT: Over the last two decades, neuroscientists have used antidepressant placebo probes to examine the biological mechanisms implicated in antidepressant placebo effects. However, findings from these studies have not yet elucidated a model-based theory that would explain the mechanism through which antidepressant expectancies evolve to induce persistent mood changes. Emerging evidence suggests that antidepressant placebo effects may be informed by models of reinforcement learning (RL). Such that an individual's expectation of improvement is updated with the arrival of new sensory evidence, by incorporating a reward prediction error (RPE), which signals the mismatch between the expected (expected value) and perceived improvement. Consistent with this framework, neuroimaging studies of antidepres

SUBMITTER: Pecina M 

PROVIDER: S-EPMC7963355 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature