Clinicopathological and immunological characterization of RNA m⁶ A methylation regulators in ovarian cancer.

ABSTRACT:

Background

N⁶ -methyladenosine (m⁶ A) modification is one of the critical gene regulatory mechanisms implicated in cancer biology. However, the roles of m⁶ A regulators in ovarian cancer are still poorly understood.

Methods

We integrated multiple databases including Gene Expression Omnibus (GEO), ROC Plotter, Kaplan-Meier Plotter, and Tumor Immune Estimation Resource (TIMER) to explore clinicopathological significance of m⁶ A regulators in ovarian cancer.

Results

We showed that alterations in the expression of m⁶ A regulators were related to the malignancy and poor prognosis of ovarian cancer. We found decreased YTHDC1 and increased RBM15 expressions were associated with ovarian cancer cell metastases and HNRNPC w

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7963423 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature