The association of MOV10 polymorphism and expression levels with preeclampsia in the Chinese Han population.

ABSTRACT:

Background

To assess the relationship between MOV10 rs2932538 polymorphism and susceptibility to preeclampsia (PE) in the Chinese Han population and to investigate whether the placental expression of MOV10 have association with PE.

Methods

We enrolled 1021 pregnant women with PE and 1594 normotensive pregnant women to analyze genotyping of MOV10 rs2932538. Clinical data and related test results of all subjects were collected and analyzed. For volunteers providing placentas, real-time PCR, Western blot, and immunohistochemistry were applied to assess the expression level of MOV10.

Results

There was significant statistical difference between preeclamptic patients and healthy subjects in genotype distributions and alleles. The frequencies of genotypes TT+CT were signific

SUBMITTER: Tang Q 

PROVIDER: S-EPMC7963431 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature