Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection.

ABSTRACT:

Objectives

Although early recognition of sepsis is vital to improving outcomes, the diagnosis may be missed or delayed in many patients. Acute kidney injury is one of the most common organ failures in patients with sepsis but may not be apparent on presentation. Novel biomarkers for acute kidney injury might improve organ failure recognition and facilitate earlier sepsis care.

Design

Retrospective, international, Sapphire study.

Setting

Academic Medical Center.

Patients

Adults admitted to the ICU without evidence of acute kidney injury at time of enrollment.

Interventions

None.

Measurements and main results

We stratified patients enrolled in the Sapphire study into three groups-those with a clinical diagnosis of sepsis (n = 216), those with infect

SUBMITTER: Kellum JA 

PROVIDER: S-EPMC7963439 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature