A Post Hoc Analysis of Osmotherapy Use in the Erythropoietin in Traumatic Brain Injury Study-Associations With Acute Kidney Injury and Mortality.

ABSTRACT:

Objectives

Mannitol and hypertonic saline are used to treat raised intracerebral pressure in patients with traumatic brain injury, but their possible effects on kidney function and mortality are unknown.

Design

A post hoc analysis of the erythropoietin trial in traumatic brain injury (ClinicalTrials.gov NCT00987454) including daily data on mannitol and hypertonic saline use.

Setting

Twenty-nine university-affiliated teaching hospitals in seven countries.

Patients

A total of 568 patients treated in the ICU for 48 hours without acute kidney injury of whom 43 (7%) received mannitol and 170 (29%) hypertonic saline.

Interventions

None.

Measurements and main results

We categorized acute kidney injury stage according to the Kidney Disease Improving Globa

SUBMITTER: Skrifvars MB 

PROVIDER: S-EPMC7963441 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature