Adaptation of spontaneous activity in the developing visual cortex.

ABSTRACT: Spontaneous activity drives the establishment of appropriate connectivity in different circuits during brain development. In the mouse primary visual cortex, two distinct patterns of spontaneous activity occur before vision onset: local low-synchronicity events originating in the retina and global high-synchronicity events originating in the cortex. We sought to determine the contribution of these activity patterns to jointly organize network connectivity through different activity-dependent plasticity rules. We postulated that local events shape cortical input selectivity and topography, while global events homeostatically regulate connection strength. However, to generate robust selectivity, we found that global events should adapt their amplitude to the history of preceding cortical act

SUBMITTER: Wosniack ME 

PROVIDER: S-EPMC7963484 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature