Longitudinal Study of Gray Matter Changes in Parkinson Disease.

ABSTRACT:

Background and purpose

The pathology of Parkinson disease leads to morphological brain volume changes. So far, the progressive gray matter volume change across time specific to patients with Parkinson disease compared controls remains unclear. Our aim was to investigate the pattern of gray matter changes in patients with Parkinson disease and to explore the progressive gray matter volume change specific to patients with Parkinson disease with disease progression by using voxel-based morphometry analysis.

Materials and methods

Longitudinal cognitive assessment and structural MR imaging of 89 patients with Parkinson disease (62 men) and 55 healthy controls (33 men) were from the Parkinson's Progression Markers Initiative data base, including the initial baseline and 12-month f

SUBMITTER: Jia X 

PROVIDER: S-EPMC7964292 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature