Imaging the intracranial atherosclerotic vessel wall using 7T MRI: initial comparison with histopathology.

ABSTRACT:

Background and purpose

Several studies have attempted to characterize intracranial atherosclerotic plaques by using MR imaging sequences. However, dedicated validation of these sequences with histology has not yet been performed. The current study assessed the ability of ultra-high-resolution 7T MR imaging sequences with different image contrast weightings to image plaque components, by using histology as criterion standard.

Materials and methods

Five specimens of the circle of Wills were imaged at 7T with 0.11 × 0.11 mm in-plane-resolution proton attenuation-, T1-, T2-, and T2*-weighted sequences (through-plane resolution, 0.11-1 mm). Tissue samples from 13 fiducial-marked locations (per specimen) on MR imaging underwent histologic processing and atherosclerotic plaque clas

SUBMITTER: van der Kolk AG 

PROVIDER: S-EPMC7964300 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature