Brain white matter involvement in hereditary spastic paraplegias: analysis with multiple diffusion tensor indices.

ABSTRACT:

Background and purpose

The hereditary spastic paraplegias are a group of genetically heterogeneous neurodegenerative disorders, characterized by progressive spasticity and weakness of the lower limbs. Although conventional brain MR imaging findings are normal in patients with pure hereditary spastic paraplegia, microstructural alteration in the cerebral WM can be revealed with DTI. Concomitant investigation of multiple intrinsic diffusivities may shed light on the neurobiologic substrate of the WM degeneration pattern in patients with pure hereditary spastic paraplegia across the whole brain.

Materials and methods

Tract-based spatial statistics analysis was performed to compare fractional anisotropy and mean, axial, and radial diffusivities of the WM skeleton in a group of 1

SUBMITTER: Aghakhanyan G 

PROVIDER: S-EPMC7964451 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature